• Record the date of the repeat cerebral MRI/MRA with evidence of stabilization of the cerebral infarct
• Specify why neurological event information was not available
• Specify why focal neurological event information was not available
• Does the patient have a history of two or more episodes of acute chest syndrome (ACS) in the two-year period preceding enrollment despite the institution of supportive care measures (i.e. asthma therapy and/or hydroxyurea)?
• Date of ACS episodes
• Specify why ACS information was not available
• Does the patient have a history of three or more severe vaso-occlusive pain crises per year in the two-year period preceding enrollment despite the institution of supportive care measures (i.e. a pain management plan and/or treatment with hydroxyurea); painful episodes related to priapism, osteonecrosis or any sickle-related complication?
• Start date of severe pain crisis 2 years prior to enrollment
• Start date of severe pain crisis 1 year prior to enrollment
• Specify why pain crises information was not available
• Has the patient received >= 8 packed red blood cell (RBC) transfusions per year for >= 1 year in the 12 months before enrollment to prevent vaso-occlusive clinical complications (i.e. pain, stroke, and acute chest syndrome)?
• Start date of RBC transfusion
• Specify why RBC transfusion therapy information was not available
• Does the patient have an echocardiographic finding of tricuspid valve regurgitant jet velocity (TRJV) >= 2.7m/sec?
• Record tricuspid valve regurgitant jet velocity (TRJV)
• Does the patient have Hemoglobin SS disease (HbSS) or Hemoglobin Sβ° (HbSβ°) Thalassemia?
• Record the type of SCD
• Performance status scale used to evaluate patient (Lansky for patients < 16 years old; Karnofsky for patients >= 16)
• Record patient's performance status
• Record the type of cardiac fraction test performed