Brevital |
Methohexital |
C66116 |
NCI Thesaurus |
A rapid, short-acting barbituric acid derivative, with anesthetic activity. Methohexital binds to the chloride ionophore site of the gamma-aminobutyric acid (GABA)-A/chloride ionophore receptor complex, thereby enhancing the inhibitory actions of GABA-A in the brain. This leads to synaptic inhibition, decreased neuronal excitability, and induction of anesthesia. In addition, this agent decreases glutamate (Glu) responses. |
Etomidate |
Etomidate |
C47527 |
NCI Thesaurus |
No value exists. |
Ketamine |
Ketamine |
C61797 |
NCI Thesaurus |
A cyclohexanone derivative with analgesic and anesthetic properties. Although its mechanism of action is not well understood, ketamine appears exerts complex pharmacological actions including inhibition of biogenic amine uptake, binding to opioid receptors, and inhibition of N-methyl D-aspartate (NMDA) receptors. Because of the involvement of spinal NMDA receptors in the process of central sensitization, this agent may reduce pain perception and induce sedation. |
Other IV Anesthesia Agents (specify) |
Other |
C17649 |
NCI Thesaurus |
Different than the one(s) previously specified or mentioned. |
Propofol |
Propofol |
C29384 |
NCI Thesaurus |
A hypnotic alkylphenol derivative. Formulated for intravenous induction of sedation and hypnosis during anesthesia, propofol facilitates inhibitory neurotransmission mediated by gamma-aminobutyric acid (GABA). This agent is associated with minimal respiratory depression and has a short half-life with a duration of action of 2 to 10 minutes. |
Sodium Thiopental |
Thiopental Sodium |
C66599 |
NCI Thesaurus |
The sodium salt form of thiopental, an ultrashort-acting barbituric acid derivative, with anesthetic activity. Thiopental binds to the chloride ionophore site of the gamma-aminobutyric acid (GABA)-A/chloride ionophore receptor complex, thereby enhancing the inhibitory actions of GABA-A in the brain. This leads to synaptic inhibition, decreased neuronal excitability and induction of anesthesia. In addition, this agent decreases glutamate (Glu) responses. |