NIH Common Data Elements (CDE) Repository

Permissible Values:

Value	Code Name	Code Description
OXPHOS enzymology	OXPHOS enzymology	OXPHOS enzymology
High resolution respirometry	High resolution respirometry	High resolution respirometry
Coenzyme Q10	Coenzyme Q10	Coenzyme Q10
Intracellular glutathione	Intracellular glutathione	Intracellular glutathione
DNA strand breaks by comet assay (cultured cells)	DNA strand breaks by comet assay (cultured cells)	DNA strand breaks by comet assay (cultured cells)
Micronucleus assay followed by fluorescense in situ hybridisation	Micronucleus assay followed by fluorescense in situ hybridisation	Micronucleus assay followed by fluorescense in situ hybridisation
pyruvate dehydrogenase	pyruvate dehydrogenase	pyruvate dehydrogenase

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Document:: Atkuri, K.R., et al., Inherited Disorders Affecting Mitochondrial Function are Associated with Glutathione Deficiency and Hypocitrullinemia. Proc Natl Acad SCI U S A, 2009. 106(10): P. 3941-5. Kramer, P.A., et al., A Review of the Mitochondrial and Glcolytic Metabolism in Human Platelets and Leukocytes: Implications for their Use as Bioenergetic Biomarkers. REdox Biol, 2014. 2: P. 206-210. Tomasetti, M., et al., Coenzyme Q10 Enrichment Decreases Oxidative DNA Damage in Human Lymphocytes. Free Radic Biol Med, 1999. 27(9-10): P. 1027-32. Migliore, L., ET AL., Evaluation of Cytogenetic and DNA Damage in Mitochondrial Disease Patients: Effects of Coenzyme Q10 Therapy. Mutagenesis, 2004. 19(1): P. 43-9. Naccarati, A., ET AL., Cytogenetic Damage in Peripheral Lympocytes of Mitochondrial Disease Patients. Neurol SCI, 2000. 21(5 SUPPL): P. S963-5. Vallance, H.D., J.R. Toone, and D.A. Applegarth, Measurement of Pyruvate Dehydrogenase (PDHC) in Interleukin-2 (IL-2) Stimulated Lymphocytes. J Inherit Metab Dis, 1994. 17(5): P. 627-8. Fouque, F., et al., Differential Effect of DCA Treatment on the Pyruvate Dehydrogenase Complex in Patients with Severe PDHC Deficiency. Pediatr Res, 2003. 53(5): P. 793-9.