Active internal bleeding (<22 days) |
Active internal bleeding (<22 days) |
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Active internal bleeding (<22 days) |
CT findings (ICH, SAH, or major infarct signs) |
CT findings (ICH, SAH, or major infarct signs) |
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CT findings (ICH, SAH, or major infarct signs) |
History of intracranial hemorrhage or brain aneurysm or vascular malformation or brain tumor |
History of intracranial hemorrhage or brain aneurysm or vascular malformation or brain tumor |
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History of intracranial hemorrhage or brain aneurysm or vascular malformation or brain tumor |
Platelets <100,000, PTT> 40 sec after heparin use, or PT > 15 or INR > 1.7, or known bleeding diathesis |
Platelets <100,000, PTT> 40 sec after heparin use, or PT > 15 or INR > 1.7, or known bleeding diathesis |
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Platelets <100,000, PTT> 40 sec after heparin use, or PT > 15 or INR > 1.7, or known bleeding diathesis |
Recent intracranial or spinal surgery, head trauma, or stroke (<3 mo.) |
Recent intracranial or spinal surgery, head trauma, or stroke (<3 mo.) |
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Recent intracranial or spinal surgery, head trauma, or stroke (<3 mo.) |
Recent surgery/trauma (<15 days) |
Recent surgery/trauma (<15 days) |
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Recent surgery/trauma (<15 days) |
SBP > 185 or DBP > 110 mmHg despite treatment |
SBP > 185 or DBP > 110 mmHg despite treatment |
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SBP > 185 or DBP > 110 mmHg despite treatment |
Seizure at onset |
Seizure at onset |
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Seizure at onset |
Suspicion of subarachnoid hemorrhage |
Suspicion of subarachnoid hemorrhage |
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Suspicion of subarachnoid hemorrhage |
Subacute Bacterial Endocarditis (SBE) |
Subacute Bacterial Endocarditis (SBE) |
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Subacute Bacterial Endocarditis (SBE) |
Advanced age |
Advanced age |
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Advanced age |
Care-team unable to determine eligibility |
Care-team unable to determine eligibility |
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Care-team unable to determine eligibility |
Glucose < 50 or > 400 mg/dl |
Glucose < 50 or > 400 mg/dl |
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Glucose < 50 or > 400 mg/dl |
Increased risk of bleeding due to Acute pericarditis, SBE, Hemostatic defects, Diabetic hemorrhagic retinopathy, Septic thrombophlebitis/occluded AV cannula, or currently receiving oral anticoagulants |
Increased risk of bleeding due to Acute pericarditis, SBE, Hemostatic defects, Diabetic hemorrhagic retinopathy, Septic thrombophlebitis/occluded AV cannula, or currently receiving oral anticoagulants |
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Increased risk of bleeding due to Acute pericarditis, SBE, Hemostatic defects, Diabetic hemorrhagic retinopathy, Septic thrombophlebitis/occluded AV cannula, or currently receiving oral anticoagulants |
IV or IA tPA given at outside hospital |
IV or IA tPA given at outside hospital |
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IV or IA tPA given at outside hospital |
Left heart thrombus |
Left heart thrombus |
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Left heart thrombus |
Life expectancy < 1 year or severe co-morbid illness or CMO on admission |
Life expectancy < 1 year or severe co-morbid illness or CMO on admission |
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Life expectancy < 1 year or severe co-morbid illness or CMO on admission |
Pregnancy |
Pregnancy |
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Pregnancy |
Patient/Family refused |
Patient/Family refused |
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Patient/Family refused |
Rapid improvement |
Rapid improvement |
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Rapid improvement |
Stroke severity - Too severe (e.g., NIHSS >22) |
Stroke severity - Too severe (e.g., NIHSS >22) |
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Stroke severity - Too severe (e.g., NIHSS >22) |
Age > 80 |
Age > 80 |
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Age > 80 |
Prior Stroke and Diabetes |
Prior Stroke and Diabetes |
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Prior Stroke and Diabetes |
Any anticoagulant use prior to admission (even if INR < 1.7) |
Any anticoagulant use prior to admission (even if INR < 1.7) |
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Any anticoagulant use prior to admission (even if INR < 1.7) |
NIHSS > 25 |
NIHSS > 25 |
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NIHSS > 25 |
CT findings of >1/3 MCA |
CT findings of >1/3 MCA |
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CT findings of >1/3 MCA |
Delay in Patient Arrival |
Delay in Patient Arrival |
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Delay in Patient Arrival |
Delay in Stroke diagnosis |
Delay in Stroke diagnosis |
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Delay in Stroke diagnosis |
In-hospital Time Delay |
In-hospital Time Delay |
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In-hospital Time Delay |
No IV access |
No IV access |
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No IV access |
Other, specify |
Other, specify |
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Other, specify |
Stroke severity nondisabling |
Stroke severity nondisabling |
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Stroke severity nondisabling |
MRI not feasible |
MRI not feasible |
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MRI not feasible |
CTP not feasible |
CTP not feasible |
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CTP not feasible |