Conditioned Place Preference Test - neurological status of the animal type

General Details:

Name:
Conditioned Place Preference Test - neurological status of the animal type
Steward:
NINDS
Definition:
Type of neurological status of the animal, as part of Conditioned Place Preference Test
Registration Status:
Qualified

Permissible Values:

Data Type:
Value List
Unit of Measure:
Ids:
Value Code Name Code Code System Code Description
1 Normal
2 Abnormal
3 Unknown

Designations:

Designation:
Conditioned Place Preference Test - neurological status of the animal type
Tags:
Designation:
What was the animal's neurological status during the conditioned place preference test trial
Tags:
Preferred Question Text

Designations:

Definition:
Type of neurological status of the animal, as part of Conditioned Place Preference Test
Tags:
Short Description,Definition

Reference Documents:

ID:
Title:
Development of CGRP-dependent pain and headache related behaviours in a rat model of concussion: Implications for mechanisms of post-traumatic headache.
URI:
https://www.ncbi.nlm.nih.gov/pubmed/?term=27899434
Provider Org:
Language Code:
en-us
Document:
Posttraumatic headache (PTH) is one of the most common, debilitating and difficult symptoms to manage after a mild traumatic brain injury, or concussion. However, the mechanisms underlying PTH remain elusive, in part due to the lack of a clinically relevant animal model. Here, we characterized for the first time, headache and pain-related behaviours in a rat model of concussion evoked by a mild closed head injury (mCHI) - the major type of military and civilian related trauma associated with PTH - and tested responses to current and novel headache therapies.Concussion was induced in adult male rats using a weight-drop device. Characterization of headache and pain related behaviours included assessment of cutaneous tactile pain sensitivity, using von Frey monofilaments, and ongoing pain using the conditioned place preference or aversion (CPP/CPA) paradigms. Sensitivity to headache/migraine triggers was tested by exposing rats to low-dose glyceryl trinitrate (GTN). Treatments included acute systemic administration of sumatriptan and chronic systemic administration of a mouse anti-CGRP monoclonal antibody.Concussed rats developed cephalic tactile pain hypersensitivity that was resolved by two weeks post-injury and was ameliorated by treatment with sumatriptan or anti-CGRP monoclonal antibody. Sumatriptan also produced CPP seven days post mCHI, but not in sham animals. Following the resolution of the concussion-evoked cephalic hypersensitivity, administration of GTN produced a renewed and pronounced cephalic pain hypersensitivity that was inhibited by sumatriptan or anti-CGRP antibody treatment as well as a CGRP-dependent CPA. GTN had no effect in sham animals.Concussion leads to the development of headache and pain-related behaviours, in particular sustained enhanced responses to GTN, that are mediated through a CGRP-dependent mechanism. Treatment with anti-CGRP antibodies may be a useful approach to treat PTH.
ID:
Title:
The Behavioral Assessment of Sensorimotor Processes in the Mouse: Acoustic Startle, Sensory Gating, Locomotor Activity, Rotarod, and Beam Walking.
URI:
https://www.ncbi.nlm.nih.gov/pubmed/?term=21204341
Provider Org:
Language Code:
en-us
Document:
Assessment of sensorimotor competence is an important part of the evaluation of animal behavior. Measurement of sensorimotor performance is of obvious importance in investigations of sensory or motor processes; however, the effects of experimental manipulations on sensorimotor performance have broader implications for behavioral neuroscience because behavioral experiments typically measure motor responses to sensory information. Thus, the results of behavioral experiments designed to assess other neurobiological processes often cannot be properly interpreted without considering concomitant effects on sensorimotor function. For example, if a lesion or genetic manipulation impairs performance on a spatial memory test, such as the radial arm maze, this impairment cannot be interpreted as evidence of cognitive dysfunction unless it is first established that it is not the result of sensorimotor deficits. Moreover, sensorimotor effects of manipulations can often be used in animal models as surrogates for effects that are more difficult to measure, and relatively simple variations of sensorimotor measures can be used as indices of performance in other behavioral domains, including cognition and emotion. A number of behavioral tasks have been designed to assess sensorimotor performance in rodents, and this chapter focuses on five general procedures—acoustic startle, sensory gating, open field exploration, rotarod, and beam walking.
ID:
Title:
The Behavioral Assessment of Sensorimotor Processes in the Mouse: Acoustic Startle, Sensory Gating, Locomotor Activity, Rotarod, and Beam Walking.
URI:
https://www.ncbi.nlm.nih.gov/pubmed/?term=21204341
Provider Org:
Language Code:
en-us
Document:

Properties:

Key:
Keywords
Value:
Preclinical;Conditioned_Place_Preference_Test ;CPP
Key:
Guidelines/Instructions
Value:
Record the animal's neurological status during the conditioned place preference test trial. Normal is the neurological status that resembles a na�ve sex and age matched animal of the same strain that is typical of the strain in regards to motor behavior, alertness, posture, reaction to visual/auditory/sensory stimuli, and behavior towards other animals of the same strain. Abnormal is the neurological status that deviates from the normal in the aspect mentioned in the previous sentence (e.g., asymmetric or unusual gait or posture, weakness bilateral or focal, lack or excessive reactivity to sensory stimuli, hypoactivity or decreased alertness, unusual behavior towards other animals of the same strain). Unknown is the status that for various reasons cannot be defined as normal or abnormal (e.g., appropriate test not done or inconclusive).

Identifiers:

Source:
NLM
Id:
Q175_ifo4
Version:
1.0
Source:
BRICS Variable Name
Id:
CPPTTrialNeurologicalStatusTyp
Version: