Conditioned Place Preference Test - seizures count
General Details:
Name:
Conditioned Place Preference Test - seizures count
Steward:
NINDS
Definition:
Count of seizures in a trial of the Conditioned Place Preference Test
Registration Status:
Qualified
Permissible Values:
Data Type:
Number
Unit of Measure:
Ids:
Value
Code Name
Code
Code System
Code Description
Designations:
Designation:
Conditioned Place Preference Test - seizures count
Tags:
Designation:
How many seizures were observed in a trial of the conditioned place preference test
Tags:
Preferred Question Text
Designations:
Definition:
Count of seizures in a trial of the Conditioned Place Preference Test
Tags:
Short Description,Definition
Reference Documents:
ID:
Title:
Development of CGRP-dependent pain and headache related behaviours in a rat model of concussion: Implications for mechanisms of post-traumatic headache.
Posttraumatic headache (PTH) is one of the most common, debilitating and difficult symptoms to manage after a mild traumatic brain injury, or concussion. However, the mechanisms underlying PTH remain elusive, in part due to the lack of a clinically relevant animal model. Here, we characterized for the first time, headache and pain-related behaviours in a rat model of concussion evoked by a mild closed head injury (mCHI) - the major type of military and civilian related trauma associated with PTH - and tested responses to current and novel headache therapies.Concussion was induced in adult male rats using a weight-drop device. Characterization of headache and pain related behaviours included assessment of cutaneous tactile pain sensitivity, using von Frey monofilaments, and ongoing pain using the conditioned place preference or aversion (CPP/CPA) paradigms. Sensitivity to headache/migraine triggers was tested by exposing rats to low-dose glyceryl trinitrate (GTN). Treatments included acute systemic administration of sumatriptan and chronic systemic administration of a mouse anti-CGRP monoclonal antibody.Concussed rats developed cephalic tactile pain hypersensitivity that was resolved by two weeks post-injury and was ameliorated by treatment with sumatriptan or anti-CGRP monoclonal antibody. Sumatriptan also produced CPP seven days post mCHI, but not in sham animals. Following the resolution of the concussion-evoked cephalic hypersensitivity, administration of GTN produced a renewed and pronounced cephalic pain hypersensitivity that was inhibited by sumatriptan or anti-CGRP antibody treatment as well as a CGRP-dependent CPA. GTN had no effect in sham animals.Concussion leads to the development of headache and pain-related behaviours, in particular sustained enhanced responses to GTN, that are mediated through a CGRP-dependent mechanism. Treatment with anti-CGRP antibodies may be a useful approach to treat PTH.
ID:
Title:
Contextually Induced Drug Seeking During Protracted Abstinence in Rats.
Over the past half century great strides have been made in the development of useful animal models for the drug abuse triad—self-administration, physical or psychological dependence, and withdrawal. In fact, the compulsion to self-administer cocaine even in the face of adverse consequences is not limited to human beings [1,2]. Practically, it is not that difficult to detoxify a drug addict, but the problem lies in the propensity for former addicts to relapse to drug-seeking behavior, a risk factor that does not appear to decrease in potency over time. Recently there has been an increasing focus on the issue of protracted withdrawal. This feature of drug addiction mirrors classical conditioning in that certain contextual cues or environmental stimuli associated with drug taking can readily initiate a form of withdrawal or craving in addicts that often leads to renewed drug seeking and relapse (for review, see [3–5]). Indeed, both the rat and human share common triggers of relapse, including the drug of abuse itself, stress, and stimuli or the environment conditioned to the drug of abuse [6]. Rodent models of human drug craving and relapse have used paradigms of extinction and reinstatement. Such models have shown predictive validity by demonstrating that clinically effective anti-craving drugs reduce drug-seeking behavior as a component of the model [7].
ID:
Title:
Development of CGRP-dependent pain and headache related behaviours in a rat model of concussion: Implications for mechanisms of post-traumatic headache.