NIH Common Data Elements (CDE) Repository

Permissible Values:

Value	Code Name	Code Description
Gomori trichrome	Gomori trichrome	Gomori trichrome
succinate dehydrogenase (SDH)	succinate dehydrogenase (SDH)	succinate dehydrogenase (SDH)
Cytochrome c Oxidase (COX) (Complex IV)	Cytochrome c Oxidase (COX) (Complex IV)	Cytochrome c Oxidase (COX) (Complex IV)
Combined SDH+COX	Combined SDH+COX	Combined SDH+COX
Fibroblast growth factor 21 (fg21)	Fibroblast growth factor 21 (fg21)	Fibroblast growth factor 21 (fg21)
OXPHOS subunit immunochemistry	OXPHOS subunit immunochemistry	OXPHOS subunit immunochemistry
Humanin immunochemistry	Humanin immunochemistry	Humanin immunochemistry

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Document:: Davis, R.L., et al., Fibroblast Growth Factor 21 is a Sensitive Biomarker of Mitochondrial Disease. Neurology, 2013. 81(21): P. 1819-26. Suomalainen, A., et al., FGF-21 as a Biomarker for Muscle-Manifesting Respiratory Chain Deficiencies: A Diagnostic Study. Lancet Neurol, 2011. 10(9): P. 806-18. Tyynismaa, H., et al., Mitochondrial Myopathy Induces a Starvation-like Response. Hum Mol Genet, 2010. 19(20): P. 3948-58. Filosto, M., et al., Neuropathology of Mitochondrial Diseases. Biosci Rep, 2007. 27(1-3): P. 23-30. Ross, J.M., Visualization of Mitochondrial Respiratory Function Using Cytochrome C Oxidase/Succinate Dehydrogenase (COX/SDH) Double-labeling Histochemistry. J Vis Exp, 2011(57): P. E3266. De Paepe, B., et al., Immunohistochemical Analysis of the Oxidative Phosphorylation Complexes in Skeletal Muscle from Patients with Mitochondrial DNA Encoded tRNA gene Defects. J Clin Pathol, 2009. 62(2): P. 172-6. Kin, T., et al., Humanin Expression in Skeletal Muscles of Patients with Chronic Progressive Extrenal Ophthalmoplegia. J Hum Genet, 2006. 51(6): P. 555-8.