Novel Object Recognition (NOR) - Post Injury Start

General Details:

Name:
Novel Object Recognition (NOR) - Post Injury Start
Steward:
NINDS
Definition:
Days post injury animals were injured at the start of test, as part of Novel Object Recognition (NOR)
Registration Status:
Qualified

Permissible Values:

Value Type:
Number
Unit of Measure:
Ids:
Value Code Name Code Code System Code Description

Designations:

Designation:
Novel Object Recognition (NOR) - Post Injury Start
Tags:
Designation:
Count days post injury animals were injured at the start of test
Tags:
Preferred Question Text

Designations:

Definition:
Days post injury animals were injured at the start of test, as part of Novel Object Recognition (NOR)
Tags:
Definition
Definition:
Days post injury animals were injured at the start of test
Tags:
Short Description

Reference Documents:

ID:
Title:
Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'.
URI:
https://www.ncbi.nlm.nih.gov/pubmed/?term=17406415
Provider Org:
Language Code:
en-us
Document:
Rats and mice have a tendency to interact more with a novel object than with a familiar object. This tendency has been used by behavioral pharmacologists and neuroscientists to study learning and memory. A popular protocol for such research is the object-recognition task. Animals are first placed in an apparatus and allowed to explore an object. After a prescribed interval, the animal is returned to the apparatus, which now contains the familiar object and a novel object. Object recognition is distinguished by more time spent interacting with the novel object. Although the exact processes that underlie this 'recognition memory' requires further elucidation, this method has been used to study mutant mice, aging deficits, early developmental influences, nootropic manipulations, teratological drug exposure and novelty seeking.
ID:
Title:
Repetitive Mild Traumatic Brain Injury in the Developing Brain: Effects on Long-Term Functional Outcome and Neuropathology.
URI:
https://www.ncbi.nlm.nih.gov/pubmed/?term=26214116
Provider Org:
Language Code:
en-us
Document:
Although accumulating evidence suggests that repetitive mild TBI (rmTBI) may cause long-term cognitive dysfunction in adults, whether rmTBI causes similar deficits in the immature brain is unknown. Here we used an experimental model of rmTBI in the immature brain to answer this question. Post-natal day (PND) 18 rats were subjected to either one, two, or three mild TBIs (mTBI) or an equivalent number of sham insults 24 h apart. After one or two mTBIs or sham insults, histology was evaluated at 7 days. After three mTBIs or sham insults, motor (d1-5), cognitive (d11-92), and histological (d21-92) outcome was evaluated. At 7 days, silver degeneration staining revealed axonal argyrophilia in the external capsule and corpus callosum after a single mTBI, with a second impact increasing axonal injury. Iba-1 immunohistochemistry showed amoeboid shaped microglia within the amygdalae bilaterally after mTBI. After three mTBI, there were no differences in beam balance, Morris water maze, and elevated plus maze performance versus sham. The rmTBI rats, however, showed impairment in novel object recognition and fear conditioning. Axonal silver staining was observed only in the external capsule on d21. Iba-1 staining did not reveal activated microglia on d21 or d92. In conclusion, mTBI results in traumatic axonal injury and microglial activation in the immature brain with repeated impact exacerbating axonal injury. The rmTBI in the immature brain leads to long-term associative learning deficit in adulthood. Defining the mechanisms damage from rmTBI in the developing brain could be vital for identification of therapies for children.
ID:
Title:
Repetitive Mild Traumatic Brain Injury in the Developing Brain: Effects on Long-Term Functional Outcome and Neuropathology.
URI:
https://www.ncbi.nlm.nih.gov/pubmed/?term=26214116
Provider Org:
Language Code:
en-us
Document:

Properties:

Key:
Keywords
Value:
Preclinical;All_Tests

Identifiers:

Source:
NLM
Id:
XJ9AKiGsV
Version:
1.0
Source:
BRICS Variable Name
Id:
NORPostInjuryStartDayCt
Version: