Opiate Agent Preoperative Intravenous Administration Name

General Details:

Name:
Opiate Agent Preoperative Intravenous Administration Name
Steward:
NCI
Definition:
The name of the opiate drug(s) administered intravenously prior to surgery in order to induce a total or partial loss of sensation especially tactile sensation and pain.
Registration Status:
Retired

Permissible Values:

Data Type:
Value List
Unit of Measure:
Ids:
Value Code Name Code Code System Code Description
Fentanyl Fentanyl C494 NCI Thesaurus A narcotic opioid drug that is used in the treatment of pain.
Hydromorphone Hydromorphone C62034 NCI Thesaurus The hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the mu-opioid receptor which is linked through G-proteins. Binding stimulates the exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP) on the G-protein complex and interacts with and inhibits adenylate cyclase located at the inner surface of the plasma membrane. This leads to a reduction in intracellular cyclic 3',5'-adenosine monophosphate (cAMP). Further, voltage-gated potassium channels are activated, thereby causing hyperpolarization and reducing neuronal excitability. In addition, the opening of voltage-gated calcium channels is inhibited, thereby leading to an inhibition of calcium entry and a reduction in the release of various neurotransmitters, including GABA, vasopressin, somatostatin, insulin and glucagons.
Meperidine Meperidine C71632 NCI Thesaurus A synthetic piperidine ester with opioid analgesic activity. Meperidine mimics the actions of endogenous neuropeptides via opioid receptors, thereby producing the characteristic morphine-like effects on the mu-opioid receptor, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia and physical dependence.
Morphine Morphine C62051 NCI Thesaurus An opiate alkaloid isolated from the plant Papaver somniferum and produced synthetically. Morphine binds to and activates specific opiate receptors (delta, mu and kappa), each of which are involved in controlling different brain functions. In the central nervous and gastrointestinal systems, this agent exhibits widespread effects including analgesia, anxiolysis, euphoria, sedation, respiratory depression, and gastrointestinal system smooth muscle contraction. (NCI04)
Other IV Opiates (specify) Other C17649 NCI Thesaurus Different than the one(s) previously specified or mentioned.

Designations:

Designation:
Opiate Agent Preoperative Intravenous Administration Name
Tags:
Long Name
Designation:
Pre-operative IV Opiates
Tags:
Preferred Question Text

Designations:

Definition:
The name of the opiate drug(s) administered intravenously prior to surgery in order to induce a total or partial loss of sensation especially tactile sensation and pain.
Tags:
Long Name
Definition:
Pre-operative IV Opiates
Tags:
Preferred Question Text

Properties:

Key:
caDSR_Context
Value:
BBRB
Key:
caDSR_Short_Name
Value:
OPIATE_PREOP_IV_NAME

Identifiers:

Source:
NLM
Id:
mkzphR7cWz
Version:
1
Source:
caDSR
Id:
5214779
Version:
1