NIH Common Data Elements (CDE) Repository

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Name:: Childhood AIS standardized classification and diagnostic evaluation (CASCADE) - standard primary acute sub type
Steward:: NINDS
Definition:: Childhood AIS Standardized Classification and Diagnostic Evaluation (CASCADE) Primary Classification: Acute - All patients with defined childhood arterial ischemic stroke will be classified into a single acute primary category, at the time of initial diagnosis (within 1 month of presentation).
Registration Status:: Qualified

Value	Code Name	Code Description
Small vessel arteriopathy of childhood (SVA)	Small vessel arteriopathy of childhood (SVA)	Small vessel arteriopathy of childhood (SVA)
Unilateral focal cerebral arteriopathy of childhood (FCA)	Unilateral focal cerebral arteriopathy of childhood (FCA)	Unilateral focal cerebral arteriopathy of childhood (FCA)
Bilateral cerebral arteriopathy of childhood	Bilateral cerebral arteriopathy of childhood	Bilateral cerebral arteriopathy of childhood
Aortic/ cervical arteriopathy	Aortic/ cervical arteriopathy	Aortic/ cervical arteriopathy
Cardio- embolic	Cardio- embolic	Cardio- embolic
Other	Other	Other
Multi-factorial	Multi-factorial	Multi-factorial
Undetermined etiology	Undetermined etiology	Undetermined etiology

Designation:: Childhood AIS standardized classification and diagnostic evaluation (CASCADE) - standard primary acute sub type
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Definition:: Childhood AIS Standardized Classification and Diagnostic Evaluation (CASCADE) Primary Classification: Acute - All patients with defined childhood arterial ischemic stroke will be classified into a single acute primary category, at the time of initial diagnosis (within 1 month of presentation).
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Document:: Bernard TJ, Beslow LA, Manco-Johnson MJ, Armstrong-Wells J, Boada R, Weitzenkamp D, Hollatz A, Poisson S, Amlie-Lefond C, Lo W, deVeber G, Goldenberg NA, Dowling MM, Roach ES, Fullerton HJ, Benseler SM, Jordan LC, Kirton A, Ichord RN. Inter-Rater Reliability of the CASCADE Criteria: Challenges in Classifying Arteriopathies. Stroke. 2016;47(10):2443-2449.<br /><br />Bernard TJ, Manco-Johnson MJ, Lo W, MacKay MT, Ganesan V, DeVeber G, Goldenberg NA, Armstrong-Wells J, Dowling MM, Roach ES, Tripputi M, Fullerton HJ, Furie KL, Benseler SM, Jordan LC, Kirton A, Ichord R. Towards a consensus-based classification of childhood arterial ischemic stroke. Stroke. 2012;43(2):371-377.