Celiac sprue assay proto

General Details:

Name:
Celiac sprue assay proto
Steward:
PhenX
Definition:
This protocol uses two-step serologic testing of serum to determine the presence of antihuman recombinant tissue transglutaminase (TTG) and endomysial antibody (EMA). When both tests are positive, the subject is notified that they are positive for celiac sprue. The test is most accurate if patients have not been on a gluten-free diet in the weeks leading up to the assay, as a gluten-free diet may cause the serologic assays to normalize in many patients. It is important that the patients screened with this laboratory assay are eating a diet that contains dietary sources of gluten in order for the assay to be most accurate. Sources of dietary gluten include the grains wheat, rye, and barley. The Gastrointestinal Working Group (WG) also recommends performing the immunoglobulin A (IgA) and immunoglobulin G (IgG) antibody tests for more sensitivity. The National Health and Nutrition Examination Survey (NHANES) uses red-top tubes to collect 0.5 ml serum for the antihuman recombinant tissue transglutaminase (TTG)/ endomysial antibody (EMA) bioassay. However, the Gastrointestinal Working Group recommends consulting the laboratory that will perform the bioassay regarding the appropriate collection tubes to use.
Registration Status:
Qualified

Designations:

Designation:
Celiac sprue assay proto
Tags:
Short Name
Designation:
PhenX - celiac sprue assay protocol 190301
Tags:
Long Common Name

Designations:

Definition:
This protocol uses two-step serologic testing of serum to determine the presence of antihuman recombinant tissue transglutaminase (TTG) and endomysial antibody (EMA). When both tests are positive, the subject is notified that they are positive for celiac sprue. The test is most accurate if patients have not been on a gluten-free diet in the weeks leading up to the assay, as a gluten-free diet may cause the serologic assays to normalize in many patients. It is important that the patients screened with this laboratory assay are eating a diet that contains dietary sources of gluten in order for the assay to be most accurate. Sources of dietary gluten include the grains wheat, rye, and barley. The Gastrointestinal Working Group (WG) also recommends performing the immunoglobulin A (IgA) and immunoglobulin G (IgG) antibody tests for more sensitivity. The National Health and Nutrition Examination Survey (NHANES) uses red-top tubes to collect 0.5 ml serum for the antihuman recombinant tissue transglutaminase (TTG)/ endomysial antibody (EMA) bioassay. However, the Gastrointestinal Working Group recommends consulting the laboratory that will perform the bioassay regarding the appropriate collection tubes to use.
Tags:
Source: Regenstrief LOINC

Reference Documents:

ID:
Title:
URI:
Provider Org:
Language Code:
en-US
Document:
Centers for Disease Control and Prevention (CDC). National Center for Health Statistics (NCHS). National Health and Nutrition Examination Survey Questionnaire. Laboratory Procedures Manual. Hyattsville, MD: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, 2009-2010.
ID:
Title:
URI:
Provider Org:
Language Code:
en-US
Document:
Dieterich, W., Ehnis, T., Bauer, M., Donner, P., Volta, U., Riecken, E. O., & Schuppan, D. (1997). Identification of tissue transglutaminase as the autoantigen of celiac disease. National Medicine, 3(7), 797–801.
ID:
Title:
URI:
Provider Org:
Language Code:
en-US
Document:
Dieterich, W., Laag, E., Schopper, H., Volta, U., Ferguson, A., Gillett, H., Riecken, E. O., & Schuppan, D. (1998). Autoantibodies to tissue transglutaminase as predictors of celiac disease. Gastroenterology, 115(6), 1317–1321.
ID:
Title:
URI:
Provider Org:
Language Code:
en-US
Document:
Green, P. H., Rostami, K., & Marsh, M. N. (2005). Diagnosis of coeliac disease. Best Practice and Research Clinical Gastroenterology, 19(3), 389–400.

Properties:

Key:
Related Names
Value:
PanPanelPANEL.PHENX
PanlPnlPoint in time
Random
Key:
Related Codes
Value:
Code SystemCodeCode TextCode Version
https://www.phenxtoolkit.org190301celiac_sprue_assay
Key:
Fully-Specified Name
Value:
ComponentPropertyTimeSystemScaleMethod
PhenX - celiac sprue assay protocol 190301-Pt^Patient-PhenX
Key:
Basic Attributes
Value:
ClassTypeFirst ReleasedLast UpdatedChange ReasonPanel Type
PANEL.PHENXClinicalVersion 2.36Version 2.67Updated the PhenX ID from "PhenX." to "PX" in Survey Question Source field to align with the variable identifier used in the PhenX Toolkit.; Added the PhenX protocol ID to the Component to clearly define the protocol version for which this panel is based upon.Panel

Identifiers:

Source:
NLM
Id:
Xk_kofp2ie
Version:
1.0
Source:
PhenX
Id:
190301
Version:
Source:
LOINC
Id:
62957-6
Version:
2.69