A fluid percussion model of experimental brain injury in the rat.
URI:
https://www.ncbi.nlm.nih.gov/pubmed/?term=3598659
Provider Org:
Language Code:
en-us
Document:
Fluid percussion models produce brain injury by rapidly injecting fluid volumes into the cranial cavity. The authors have systematically examined the effects of varying magnitudes of fluid percussion injury in the rat on neurological, systemic physiological, and histopathological changes. Acute neurological experiments showed that fluid percussion injury in 53 rats produced either irreversible apnea and death or transient apnea (lasting 54 seconds or less) and reversible suppression of postural and nonpostural function (lasting 60 minutes or less). As the magnitude if injury increased, the mortality rate and the duration of suppression of somatomotor reflexes increased. Unlike other rat models in which concussive brain injury is produced by impact, convulsions were observed in only 13% of survivors. Transient apnea was probably not associated with a significant hypoxic insult to animals that survived. Ten rats that sustained a moderate magnitude of injury (2.9 atm) exhibited chronic locomotor deficits that persisted for 4 to 8 days. Systemic physiological experiments in 20 rats demonstrated that all levels of injury studied produced acute systemic hypertension, bradycardia, and increased plasma glucose levels. Hypertension with subsequent hypotension resulted from higher magnitudes of injury. The durations of hypertension and suppression of amplitude on electroencephalography were related to the magnitudes of injury. While low levels of injury produced no significant histopathological alterations, higher magnitudes produced subarachnoid and intraparenchymal hemorrhage and, with increasing survival, necrotic change and cavitation. These data demonstrate that fluid percussion injury in the rat reproduces many of the features of head injury observed in other models and species. Thus, this animal model could represent a useful experimental approach to studies of pathological changes similar to those seen in human head injury.
ID:
Title:
URI:
Provider Org:
Language Code:
en-us
Document:
Alder, J., Fujioka, W., Lifshitz, J., Crockett, D. P., Thakker-Varia, S. Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice. J. Vis. Exp. (54), e3063, doi:10.3791/3063 (2011).
ID:
Title:
Preferences for the delivery of community pharmacy services to help manage chronic conditions.
Smith Douglas H., Hicks Ramona R., Johnson Victoria E., Bergstrom Debra A., Cummings Diana M., Noble Linda J., Hovda David, Whalen Michael, Ahlers Stephen T., LaPlaca Michelle, Tortella Frank C., Duhaime Ann-Christine, and Dixon C. Edward. Journal of Neurotrauma. -Not available-, ahead of print. doi:10.1089/neu.2014.3861.
ID:
Title:
URI:
Provider Org:
Language Code:
en-us
Document:
ID:
Title:
URI:
Provider Org:
Language Code:
en-us
Document:
Johnson, S.B., Whitney, G., McAuliffe, M., Wang, H., McCreedy, E., Rozenblit, L., and Evans, C.C. (2010). Using Global Unique identifiers to link autism collections. J. Am. Med. Inform. Assoc., in press. Published online July 17, 2010. 10.1136/jamia.2009.002063.
ID:
Title:
URI:
Provider Org:
Language Code:
en-us
Document:
Aurlie Jean, Michelle K. Nyein, James Q. Zheng, David F. Moore, John D. Joannopoulos and Ral Radovitzky, An animal-to-human scaling law for blast-induced traumatic brain injury risk assessment, 2014, PNAS, http://www.pnas.org/content/111/43/15310. Ye Xiong, Asim Mahmood and Michael Chopp, Animal models of traumatic brain injury, 2013 Macmillan Publishers Limited. All rights reserved
ID:
Title:
URI:
Provider Org:
Language Code:
en-us
Document:
Alexander MS, Biering-Sorensen F, Elliott S, Kreuter M, Saanksen J. International Spinal Cord Injury Female Sexual and Reproductive Function Basic Data Set. Spinal Cord. 2011 Jul;49(7):787-90. Alexander MS, Biering-Sorensen F, Elliott S, Kreuter M, Saanksen J. International Spinal Cord Injury Male Sexual Function Basic Data Set. Spinal Cord. 2011 Jul;49(7):795-8.
Bauman WA, Biering-Sorensen F, Krassioukov A. International spinal cord injury endocrine and metabolic function basic data set. Spinal Cord. 2011 Oct;49(10):1068-72.
Biering-Sorensen F, Craggs M, Kennelly M, Schick E, Wyndaele JJ. International Lower Urinary Tract Function Basic Spinal Cord Injury Data Set. Spinal Cord 2008 May;46(5):325-30.
Krogh K, Perkash I, Stiens SA, Biering-Sorensen F. International bowel function extended spinal cord injury data set. Spinal Cord. 2009 Mar;47(3):235-41.
Widerstraam-Noga E, Biering-Sorensen F, Bryce T, Cardenas DD, Finnerup NB, Jensen MP, Richards JS, Siddall PJ. The international spinal cord injury pain basic data set. Spinal Cord. 2008 Dec;46(12):818-23.
ID:
Title:
URI:
Provider Org:
Language Code:
en-us
Document:
Scattoni et al 2011;Silverman et al 2029
ID:
Title:
URI:
Provider Org:
Language Code:
en-us
Document:
Grin'kina, et al., Righting reflex predicts long-term histological and behavioral outcomes in a closed hed model of traumati brain injury, PLoS One 2016 Sep 22;11(9)