Oral glucose tolerance test proto

General Details:

Name:
Oral glucose tolerance test proto
Steward:
PhenX
Definition:
Participants are asked to fast for at least 9 hours (generally overnight) prior to the Oral Glucose Tolerance test. Participants are asked a series of exclusionary questions and then have an initial blood draw to determine Fasting Plasma Glucose levels. Participants are next asked to drink a calibrated dose (generally 75 grams / 10 ounces) of a dextrose solution (e.g., Trutol®) and have a second venipuncture 2 hours (plus or minus 15 minutes) after the first venipuncture. The plasma is separated from the blood via centrifugation and glucose concentration is determined via the hexokinase method. The Oral Glucose Tolerance Test includes a Fasting Plasma Glucose assay as the first step. Therefore performing the Oral Glucose Tolerance Test and the Fasting Plasma Glucose Assay for Diabetes Screening together will result collecting in the Fasting Plasma Glucose Assay twice. The Diabetes Working Group notes that an alternative to the single two-hour post load value is to establish a catheter and obtain samples for Serum Glucose concentrations at 0, 30, 60, 90 and 120 minutes. There are also protocols for more rapid sampling of Serum Glucose concentrations. In addition, the Diabetes Working Group notes that there are also protocols to collect samples for Serum Insulin concentrations at 0, 30, 60, 90 and 120 minutes and that this could be done at the same time as the Oral Glucose Tolerance Test. Such protocols would give extra specificity and information but would increase the burden on both the participant and investigator.
Registration Status:
Qualified

Designations:

Designation:
Oral glucose tolerance test proto
Tags:
Short Name
Designation:
PhenX - oral glucose tolerance test protocol 141001
Tags:
Long Common Name

Designations:

Definition:
Participants are asked to fast for at least 9 hours (generally overnight) prior to the Oral Glucose Tolerance test. Participants are asked a series of exclusionary questions and then have an initial blood draw to determine Fasting Plasma Glucose levels. Participants are next asked to drink a calibrated dose (generally 75 grams / 10 ounces) of a dextrose solution (e.g., Trutol®) and have a second venipuncture 2 hours (plus or minus 15 minutes) after the first venipuncture. The plasma is separated from the blood via centrifugation and glucose concentration is determined via the hexokinase method. The Oral Glucose Tolerance Test includes a Fasting Plasma Glucose assay as the first step. Therefore performing the Oral Glucose Tolerance Test and the Fasting Plasma Glucose Assay for Diabetes Screening together will result collecting in the Fasting Plasma Glucose Assay twice. The Diabetes Working Group notes that an alternative to the single two-hour post load value is to establish a catheter and obtain samples for Serum Glucose concentrations at 0, 30, 60, 90 and 120 minutes. There are also protocols for more rapid sampling of Serum Glucose concentrations. In addition, the Diabetes Working Group notes that there are also protocols to collect samples for Serum Insulin concentrations at 0, 30, 60, 90 and 120 minutes and that this could be done at the same time as the Oral Glucose Tolerance Test. Such protocols would give extra specificity and information but would increase the burden on both the participant and investigator.
Tags:
Source: Regenstrief LOINC

Reference Documents:

ID:
Title:
URI:
Provider Org:
Language Code:
en-US
Document:
American Diabetes Association. (2009). Diagnosis and classification of diabetes mellitus. Diabetes Care, 32(Supplement 1), S62 - S67.
ID:
Title:
URI:
Provider Org:
Language Code:
en-US
Document:
American Diabetes Association. (2010). Diagnosis and classification of diabetes mellitus. Diabetes Care, 33 (Supplement 1), S11 - S61.
ID:
Title:
URI:
Provider Org:
Language Code:
en-US
Document:
Centers for Disease Control and Prevention (CDC). National Center for Health Statistics (NCHS). National Health and Nutrition Examination Survey Questionnaire. Oral Glucose Tolerance Test (OGTT) Procedures Manual. Hyattsville, MD: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, 2005-2006
ID:
Title:
URI:
Provider Org:
Language Code:
en-US
Document:
Centers for Disease Control and Prevention (CDC). National Center for Health Statistics (NCHS). National Health and Nutrition Examination Survey Questionnaire. Laboratory Procedures Manual. Hyattsville, MD: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, 2007-2008
ID:
Title:
URI:
Provider Org:
Language Code:
en-US
Document:
Centers for Disease Control and Prevention (CDC). National Center for Health Statistics (NCHS). National Health and Nutrition Examination Survey Questionnaire. Shared Exclusion Questions for the MEC Examination. Hyattsville, MD: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, 2002. (questions 6 and 7)
ID:
Title:
URI:
Provider Org:
Language Code:
en-US
Document:
American Diabetes Association. (2008). Standards of medical care in diabetes - 2008. Diabetes Care, 31(Supplement 1), S12 - S54

Properties:

Key:
Related Names
Value:
GluGlu tolGluc
GlucoseurGTTPan
PanelPANEL.PHENXPanl
PnlPoint in timeRandom
Key:
Related Codes
Value:
Code SystemCodeCode TextCode Version
https://www.phenxtoolkit.org141001oral_glucose_tolerance_test
Key:
Fully-Specified Name
Value:
ComponentPropertyTimeSystemScaleMethod
PhenX - oral glucose tolerance test protocol 141001-Pt^Patient-PhenX
Key:
Basic Attributes
Value:
ClassTypeFirst ReleasedLast UpdatedChange ReasonPanel Type
PANEL.PHENXClinicalVersion 2.36Version 2.67Updated the PhenX ID from "PhenX." to "PX" in Survey Question Source field to align with the variable identifier used in the PhenX Toolkit.; Added the PhenX protocol ID to the Component to clearly define the protocol version for which this panel is based upon.Panel

Identifiers:

Source:
NLM
Id:
mkb5sz6hsx
Version:
1.0
Source:
PhenX
Id:
141001
Version:
Source:
LOINC
Id:
62856-0
Version:
2.69